GAWRYL, MARIA S.,HOUTCHENS, ROBERT A.,LIGHT, WILLIAM R.
申请号：
CA2373753
公开号：
CA2373753C
申请日:
2000.07.07
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to a method for preserving the stability of a hemoglobinblood substitute comprising maintaining the hemoglobin blood substitute in anatmosphere substantially free of oxygen. The method for preserving adeoxygenated hemoglobin blood substitute comprises maintaining thedeoxygenated hemoglobin blood substitute in an oxygen barrier film overwrappackage. In one embodiment, the package comprises a transparent laminatematerial comprising an oxygen barrier layer and a polyolefin layer, whereinthe laminant has a thickness of between about 0.001 and about 0.01 inches (orabout 0.0254 to about 0.254 millimeters) and an oxygen permeability of lessthan about 0.01 cubic centimeters per 100 square inches (or about 0.01 cc per645 square centimeters) over 24 hours at 1 atmosphere and at about 23 ~C. Theoxygen barrier layer comprises ethylene vinyl alcohol. Aso provided herein isa preserved deoxygenated hemoglobin blood substitute comprises a deoxygenatedhemoglobin blood substitute and an oxygen barrier film overwrap package. Thepackage comprises a transparent laminant material comprising an oxygen barrierlayer and a polyolefin layer. Said oxygen barrier layer has an oxygenpermeability of less than about 0.01 cubic centimeters per 100 square inches(or about 0.01 cc per 645 square centimeters) over 24 hours at 1 atmosphereand at about 27 ~C room temperature, wherein the deoxygenated hemoglobin bloodsubstitute is sealed within the overwrap package. In one embodiment, theoxygen barrier layer comprises ethylene vinyl alcohol.
