CALIFORNIA NORTHSTATE COLLEGE OF PHARMACY, LLC; LLC;WOLDEMARIAM, TIBEBE, Z.;CALIFORNIA NORTHSTATE COLLEGE OF PHARMACY;PATHER, INDIRAN
发明人:
PATHER, INDIRAN,WOLDEMARIAM, TIBEBE, Z.
申请号：
EP13830806
公开号：
EP2887950A4
申请日:
2013.08.19
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
A method of preparing a formulation having a pharmaceutically acceptable liquid extract of Curcuma longa L, the method comprising:macerating at least a portion of a Curcuma longa L. root for an effective time in an at least substantially non-toxic extraction solvent that is miscible with phenolic diketones that include curcumin, demethoxycurcumin, and bisdemethoxycurcumin； and,pharmaceutically acceptable as a carrier for the phenolic diketones, the carrier having an acute oral toxicity with an LD50 of at least 49,700 mg/kg；wherein, the macerating includes covering the portion of the Curcuma longa L. root with the extraction solvent；separating the extraction solvent from the macerated Curcuma longa L. root to create a liquid extract of Curcuma longa L, the extract including curcumin； and,incorporating the liquid extract directly into the formulation without removal of the extraction solvent, the carrier having the acute oral toxicity with the LD50 of at least 49,700 mg/kg which is at least substantially less toxic than ethanol；wherein, the extraction solvent is selected from the group consisting of sesame oil, liquid paraffin, glycerin, squalene, cotton seed oil, liquid-grade polyethylene glycol, isopropyl myristate, polysorbate 80, and combinations thereof.
