Jotham Wadsworth Coe,Christoph Martin Dehnhardt,Peter Jones,Yogesh Anil Sabnis,Joseph Walter Strohbach,Florian Michel Wakenhut,Gavin Alistair Whitlock
申请号：
US15342601
公开号：
US10022376B2
申请日:
2016.11.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A compound having the structure:or a pharmaceutically acceptable salt or solvate thereof, wherein A and A′ are C or N, where C may be substituted by halo or C1-C6 alkyl； R and R0 are selected from the group consisting of H, C1-C6 alkyl, —(CH2)n—W, etc., where W is 5- or 6-membered heteroaryl or heterocyclic containing N, S and/or O atoms, —NR″SO2—R′, etc., where R′ and R″ are C1-C6 alkyl, etc.； wherein each alkyl, etc., may be substituted； or, R and Ro and the N atom to which they are bonded together to form a monocyclic or bicyclic heterocyclic ring, etc.； R1 is H, halo or cyano； R2 and R2′ are H, C1-C6 alkyl, etc.； X is a bond, etc.； R3 is H, C1-C4 alkyl, etc.； Y is a bond, —(CH2)m—, etc. The invention also relates to compositions and uses in the treatment of various diseases.
