CARLOS GONZÁLEZ OJER,RAQUEL MARIA DA COSTA MARTINS,JOSEP M. SUÑÉ NEGRE,MONTSERRAT MIÑARRO CARMONA,JOSEP RAMON TICÓ GRAU,ENCARNA GARCÍA MONTOYA,PILAR PÉREZ LOZANO,MANEL ROIG CARRERAS,NATALIA SÁNCHEZ PO
申请号：
PT13815447
公开号：
PT2931255T
申请日:
2013.12.16
申请国别(地区):
PT
年份:
2017
代理人:
摘要：
The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight； polyvinylpirrolidone in an amount comprised from 4 to 8% by weight； glycerine in an amount comprised from 1 to 10% by weight； and propyleneglycol in an amount comprised from 20 to 40% by weight； wherein: the weight ratio between polyvinylpirrolidone:polycarbophil is comprised between 1:1 and 4:1, the weight ratio between glycerine:polycarbophil is comprised from 0.5:1 to 2:1, and the weight ratio propyleneglycol:polycarbophil is comprised from 8:1 to 20:1. The invention also provides transparent compositions comprising such gel combinations as well as processes for their preparation and the use thereof as a medicament. Due to the specific excipients, % by weight, and weight ratios forming the combination, the resulting compositions show a high bioadhesivity and bioavailablity of the active ingredient, without toxic adverse effects.
