The invention provides novel surface coat proteins of Clostridium spp. spores, and nucleic acids encoding such proteins. The invention extends to various uses of these nucleic acids and proteins, as antigens for use in vaccine design and construction, and to vaccines per se, and in diagnostic test kits and methods for the detection of Clostridium spp. infections. In addition, the nucleic acids and proteins can be used as potential targets for therapeutic drugs for the prevention or treatment of Clostridium spp. infections.
