Method and system provided herein, influence of their base what hereditary variations to biological activity relevant to Luo Tafuxin in individual. Specifically, there is described herein such composition, method and system, their base whats between the gene of the gene in KCNS3, THSD7A, FAM46A, LOC389970, HLA-G and TTC29 or in intergenic regions one or more polymorphisms and/or with it at what linkage disequilibrium hereditary variation on the identified influence of the individual response of Luo Tafuxin.本文中提供方法和系統，它們基於遺傳性變異對個體中與羅他福辛相關的生物學活性的影響。具體而言，本文中描述了這樣的組合物、方法和系統，它們基於在選自KCNS3、THSD7A、FAM46A、LOC389970、HLA-G和TTC29中的基因的基因間或基因內區域裏一個或多個多態性和/或與其處於連鎖不平衡的遺傳性變異對羅他福辛的個體應答的經鑒定影響。
