The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.本發明闡述包含PD-1軸結合拮抗劑及MEK抑制劑之組合治療及其使用方法,包括治療需要增強免疫原性之病況之方法,例如增強腫瘤免疫原性以供治療癌症。