THE UNIVERSITY OF IOWA RESEARCH FOUNDATION;ALDERBIO HOLDINGS LLC
发明人:
Andrew F. RUSSO,Eric A. KAISER,Ana RECOBER,Adisa KUBURAS,Ann C. RADDANT,Brian R. KOVACEVICH,John LATHAM,Jeffrey T.L. SMITH,Leon F. GARCIA-MARTINEZ
申请号：
US15818000
公开号：
US20180161434A1
申请日:
2017.11.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated CGRP levels, e.g., in the GI tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. More specifically, this invention relates to treatments using the anti-CGRP antibodies and fragments described herein, and binding fragments thereof.
