MUMM, JOHN BRIAN,CHAN, IVAN HO,MCCAULEY, SCOTT,OGG, SCOTT,OFT, MARTIN
申请号：
CA3008287
公开号：
CA3008287A1
申请日:
2017.01.10
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure provides methods and compositions relating to isolated CD8+ T cells expressing a disease antigen-specific T cell receptor, as well as nucleic acids encoding the Va and Vß polypeptide pairs of T cell receptors (TCRs) of such disease antigen-specific T cells. Such disease antigen-specific CD8+ T cells are obtainable from the periphery (e.g., blood) of a subject having a disease amenable to treatment with an IL-10 agent. The present disclosure also contemplates therapeutic methods and compositions relating to administration of isolated disease antigen-specific CD8+ T cells to a subject, as well as therapeutic methods and compositions relating to CD8+ T cells genetically modified to express a disease antigen-specific TCR and/or chimeric antigen receptor.
