The invention is related to a dispense interface (402) for a drug delivery device for delivering at least two drug agents, wherein the dispense interface (402) is configured to be coupled to a cartridge holder of the drug delivery device, wherein the cartridge holder is configured to hold at least two cartridges (416, 418), wherein the dispense interface (402) comprises at least two inlet channels (404, 406), each comprising a fluid inlet opening (408, 412), wherein each fluid inlet opening (408, 412) is configured to receive fluid from a respective cartridge of the at least two cartridges (416, 418) when the dispense interface (402) is axially coupled to the cartridge holder, an outlet channel (424) comprising a fluid outlet opening (426), a valve structure (420) configured to be selectively moved into any one of a plurality of positions, wherein in at least one position the valve structure (420) selectively permits or prevents fluid flow from any of the at least two inlet channels (404, 406) to the outlet channel (424). The invention is further related to a drug delivery device for delivering at least two drug agents comprising a dispense interface (402) of the aforementioned kind.