СТИВЕНСО, Найджел Р. (US),ГОНЗАЛЕС Гилберт Р. (US)
申请号：
RU2015155001
公开号：
RU2015155001A
申请日:
2014.05.21
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
Alzheimers disease is treated by attacking hyperactive microglia preferably before excessive beta amyloid is built up by administering tin-117m-DOTA annexin V. This compound in low radioactive doses selectively binds to the aged hyperactive microglia and emits a conversion electron which effectively induces apoptosis in the hyperactive microglia. A follow-up treatment of tin-annexin A1 can be administered to repair the blood brain barrier. The annexin A1 assists in the repair of the blood-brain barrier and the associated tin-117m will induce apoptosis in aged hyperactive microglia associated with the blood brain barrier.
