As for this invention, the manner which decreases the mucus tonnage in the breath organ of the target whose mucus level of the breath organ is high is offered. This manner, shiaridaze or has the step which prescribes chemical compound or the constituent which includes the active ingredient and the fusion protein of the remedy effective tonnage which includes anchor domain for the target. This remedy effective tonnage before prescribing this chemical compound or the constituent, after prescribing this chemical compound or the constituent in comparison with the mucus tonnage, includes the tonnage of the fusion protein which decreases the mucus tonnage of the breath organ.< Choice figure >Drawing 1本発明は、呼吸器管の粘液レベルが高い対象の呼吸器管における粘液量を低下させる方法を提供する。この方法は、対象に、シアリダーゼ又はその有効成分と、アンカードメインを含む治療的有効量の融合タンパク質を含む化合物又は組成物を投与するステップを具える。この治療的有効量は、この化合物又は組成物を投与する前の粘液量に比べて、この化合物又は組成物を投与した後に呼吸器管の粘液量を低下させる融合タンパク質の量を含む。【選択図】図1
