A device and method to occlude blood flow through a subclavian artery and subclavian vein is presented. Small incisions are formed both superior and inferior to the clavicle. A closure element is introduced into one incision, passed posterior to the clavicle and vessels, and withdrawn through a second incision, such that a first end of the closure element extends from one incision and the second end extends from the other incision. The closure element is formed into a closed loop around the clavicle and vessels. The loop is tightened to occlude blood flow through the vessels. Locking features on the closure element enable rapid and secure cinching of the loop. A second closure element may be delivered through the same pathway and used for enhanced stability of the occlusion. A delivery member may be used to carry the closure element(s) through the incisions.
