COMPOSITION COMPRISING AN EXTRACT OF COMBINED CRUDE DRUG INCLUDING XANTHIUM STRUMARIUM L. FOR PREVENTING AND TREATING INFLAMMATORY DISEASE OR ALLERGIC DISEASE
재단법인 한국한방산업진흥원;INSTITUTE FOR KOREA TRADITIONAL MEDICAL INDUSTRY;명지대학교 산학협력단;CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATIONFOUNDATION;MYONGJI UNIVERSITY INDUSTRY AND ACADEMIA COOPERATION FOUNDATION
发明人:
LEE, EUN KYUNG,이은경,PARK, YOUNG NA,박영나,LEE, HWA DONG,이화동,PARK, HYO HYUN,박효현,KIM, SUN GUN,김선건,JEONG, KYU TAE,정규태,LEE, JI EAN,이지언,SUH, JOO WON,서주원,OH, EUI CHAUL,오의철,JANG, DONG JIN,장동진
申请号：
KR1020120111746
公开号：
KR1020140045693A
申请日:
2012.10.09
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to a composition for preventing and treating inflammatory diseases or allergic diseases containing a complex herbal extract containing Xanthium strumarium L., Trichosanthes fructus, Angelica dahurica root, and Mentha arvensis var. piperascens as active ingredients. The extract of the present invention controls the generation of NO and cytokine (TNF-alpha, IL-1) secreted from macrophagocyte after LPS stimulation, and has anti-inflammatory, anti-allergic, and anti-rhinitis effects controlling the generation of IL-4, IL-5, and IL-13 secreted from spleen cells and the reduction of serum IgE concentration in a rhinitis animal model induced by ovalbumin, thereby being applied to a pharmaceutical composition for preventing and treating inflammatory diseases or allergic diseases. [Reference numerals] (AA) Figure 1-A cell survival rate본 발명은 창이자, 괄루인, 백지 및 박하로 구성된 복합생약 추출물을 유효성분으로 함유하는 염증질환 또는 알레르기 질환의 예방 및 치료를 위한 조성물에 관한 것으로, 본 발명의 추출물은 LPS 자극 후 대식세포에서 분비되는 NO 및 사이토카인 (TNF-α, IL-1) 생성을 억제하며, 오브알부민에 의해 유도된 비염동물모델에서 혈청 IgE 농도 감소 및 비장세포에서 분비되는 IL-4, IL-5, 및 IL-13의 생성을 억제하는 항염증, 항알레르기 및 항비염 효과를 확인함으로써, 염증질환 또는 알레르기 질환의 예방 및 치료용 약학조성물에 이용될 수 있다.
