A system/method allowing personalized ex vivo customization of a generic ophthalmic lens blank (OLB) or ophthalmic lens with known diopter (OKD) based on localized field-measured patient characteristics is disclosed. The OLB is composed of a clear material that contains an ultraviolet (UV) absorbing compound. The refractive index of a portion of the clear material may be customized by spatial modification (CSM) of its refractive index via the use of pulsed laser radiation (PLR). The customization of clear material (i) creates a lens which cannot be created otherwise, or (ii) eliminates the need for remote laboratory fabrication of a customized intraocular lens (IOL) for the patient. The OLB is retained within a secured lens container (SLC) providing for precise physical orientation of the OLB haptics and OLB lens structure with respect to the application of PLR to the OLB. The SLC contains a lens filler material (LFM) covering the OLB and is hermetically sealed after the OLB has been positioned within the SLC interior and prior to sterilization of the SLC+OLB combination.