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GrB-EHITSN inhibitory peptides
专利权人:
Rush University Medical Center
发明人:
Sanda Predescu,Dan Predescu
申请号:
US15321109
公开号:
US10793598B2
申请日:
2015.06.19
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Fusion peptides and methods of inhibiting GrB-EHITSN or a fragment thereof are provided. The fusion peptides include an NPF peptide and a cell-permeable peptide operably connected thereto. Fusion peptides and methods of inhibiting activity of GrB-EHITSN or fragment thereof are provided. An aspect includes a fusion peptide comprising an isolated NPF peptide comprising an amino acid sequence having at least 90% identity to SEQ ID NO: 2 and a cell-permeable peptide operably connected to the isolated NPF peptide, wherein the fusion peptide inhibits activity of GrB-EHITSN or a fragment thereof.
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