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N-(4-ГИДРОКСИ-4-МЕТИЛЦИКЛОГЕКСИЛ)-4-ФЕНИЛБЕНЗОЛСУЛЬФОНАМИДЫ И N-(4-ГИДРОКСИ-4-МЕТИЛЦИКЛОГЕКСИЛ)-4-(2-ПИРИДИЛ)БЕНЗОЛСУЛЬФОНАМИДЫ И ИХ ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ
专利权人:
ПИМКО 2664 ЛИМИТЕД
发明人:
Пейтел, Лиза,Смит, Стефен Аллан,Грейг, Иан Роберт,Уильямс, Сэмюэл Кэмерон
申请号:
EA201592308
公开号:
EA201592308A1
申请日:
2014.06.24
申请国别(地区):
EA
年份:
2016
代理人:
摘要:
the present invention relates generally to the field of therapeutic compounds.in particular, the present invention relates to certain \u0437\u0430\u043c\u0435\u0449\u0435\u043d\u043d\u044b\u043c n - (4 - hmg - 4 - \u043c\u0435\u0442\u0438\u043b\u0446\u0438\u043a\u043b\u043e\u0433\u0435\u043a\u0441\u0438\u043b) - 4 - \u0444\u0435\u043d\u0438\u043b\u0431\u0435\u043d\u0437\u043e\u043b\u0441\u0443\u043b\u044c\u0444\u043e\u043d\u0430\u043c\u0438\u0434\u043d\u044b\u043c and n - (4 - 4 - \u043c\u0435\u0442\u0438\u043b\u0446\u0438\u043a\u043b\u043e\u0433\u0435\u043a\u0441\u0438\u043b hmg) 4 - (2 - \u043f\u0438\u0440\u0438\u0434\u0438\u043b) \u0431\u0435\u043d\u0437\u043e\u043b\u0441\u0443\u043b\u044c\u0444\u043e\u043d\u0430\u043c\u0438\u0434\u043d\u044b\u043c compounds (collectively, in the present paper \u043d\u043c\u0441 compounds which are suitable, for example, for the treatment of (for example, diseases)including inflammation and \/ or destruction of the joints and \/ or loss of bone tissue violations of the indirect excessive and \/ or inadequate and \/ or prolonged activation of \u0438\u043c\u043c\u0443 \u043d\u043d\u043e\u0439 system inflammatory and autoimmune disordersfor example, rheumatoid arthritis, psoriasis, psoriatic arthritis, and chronic lung disease (\u043e\u0431\u0441\u0442\u0440\u0443\u043a\u0442\u0438\u0432\u043d\u0443\u044e \u0445\u043e\u0431\u043b) asthma atherosclerosisre inflammatory disease. \u0448\u0435\u0447\u043d\u0438\u043a\u0430 ankylosing spondylitis multiple sclerosis systemic lupus \u0448\u0435\u0433\u0440\u0435\u043d\u0430 red syndrome disorder associated with loss of bone tissue, is to if the loss of bone mass.excessive activity of the osteoclasts associated with rheumatoid arthritis, osteoporosis, bone disease associated with cancer or disease \u0440\u0430\u043a\u043e\u0432\u043e\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432 ike. \u0430\u043d\u0438\u0435 \u0433\u0435\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u
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