Herbert Y. Lin,Jodie Babitt,Raymond T. Chung,Tarek A. Samad,Alan L. Schneyer,Clifford J. Woolf
申请号：
US13407502
公开号：
US20120258105A1
申请日:
2012.02.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.
