FEY GEORG H,STEIN CHRISTOPH,KELLNER CHRISTIAN,KUGLER MARKUS
申请号：
IN5939/CHENP/2012
公开号：
IN2012CN05939A
申请日:
2012.07.05
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a molecule having binding specificities for (a) CD123 (b) CD16 and (c) CD33. The present invention further relates to the molecule of the invention wherein the molecule comprises a first immunoglobulin domain comprising a VL domain linked to a VH domain wherein the immunoglobulin domain specifically binds to CD123 a second immunoglobulin domain comprising a VL domain linked to a VH domain wherein the immunoglobulin domain specifically binds to CD16 and a third immunoglobulin domain comprising a VL domain linked to a VH domain wherein the immunoglobulin domain specifically binds to CD33. The present invention furthermore relates to a nucleic acid molecule encoding the molecule of the invention. In addition the present invention relates to diagnostic and pharmaceutical compositions and the use of the molecule or the nucleic acid molecule of the invention in the treatment of acute myeloid leukaemia and/or myelodysplastic syndrome. Figure 1
