The present invention relates to an oral spray or aerosol containing palonosetron. The formulation comprises palonosetron or its pharmaceutically acceptable salts, and pharmaceutically acceptable excipients which are selected from the group consisting of buffering agents, osmotic regulators, correctants, preservatives, chelating agents, polar solvents and nonpolar solvents. The active ingredient of the spray or aerosol can be rapidly absorbed through the oral mucosa with fast on site of action and high bioavailability.本發明涉及一種含帕洛諾司瓊的口腔噴霧劑或氣霧劑,該製劑包括:帕洛諾司瓊或其可藥用的鹽、以及選自緩衝劑、滲透壓調節劑、矯味劑、防腐劑、螯合劑、極性溶劑或非極性溶劑的藥學上可接受的輔料。該噴霧劑或氣霧劑中的活性成份可通過口腔黏膜迅速吸收而快速起效,生物利用度高。
