The invention relates to the field of medicine, namely family medicine (general practitioners), therapy, endocrinology, gerontology, dermatology and cosmetology and solves the problem of restoration of epidermal lipid barrier in facial skin, decollete and the neck in metabolic syndrome patients. The goal of the invention is to develop a cream composition that restores epidermal lipid barrier and lipid layer of facial skin, neck and decollete for use in patients with metabolic syndrome. Set goals are achieved through the design of a specific ē cream composition, which contains seleno-L-methionine, Vitamin E alpha-tocopherol, squalane, methyl-4- hydroxybenzoate, glycerol monostearate 60, cetylalchol, middle chain triglyceride, white petrolatum, macrogol-20-glycerolmonostearate, 1,2-propanediol and distilled water in the certain ratios mass relationships.