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Polypeptide that binds aberrant cells and induces apoptosis
专利权人:
Maria Johanna J. E. Van Driel
发明人:
Ralph Alexander Willemsen,Maria Johanna J. E. Van Driel,Johan Renes
申请号:
US13976974
公开号:
US09821073B2
申请日:
2011.12.22
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Described are proteinaceous molecules comprising at least a domain that comprises an amino acid sequence that specifically binds to an MHC-peptide complex on an aberrant cell, functionally connected with a substance that induces apoptosis in aberrant cells, but not in normal cells. These proteinaceous molecules are preferably used in selectively modulating biological processes. The provided proteinaceous molecules are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers.
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