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A METHOD FOR INCREASING ANTIBODY-DEPENDENT CYTOTOXICITY WITH CASTANOSPERMINE
专利权人:
TRUBION PHARMACEUTICALS; INC.
发明人:
ESPLING, ERIK STEPHEN,BAUM, PETER ROBERT,THOMPSON, PETER ARMSTRONG
申请号:
AU2013201195
公开号:
AU2013201195A1
申请日:
2013.03.01
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
A composition comprising recombinant immunoglycoproteins, wherein the recombinant immunoglycoprotein molecules each comprise a binding domain that specifically binds to CD37 and have at least a 5-fold increase in antibody-dependent cellular cytotoxicity (ADCC) as compared to control immunoglycoproteins of the same encoded amino acid sequence produced in Chinese Hamster Ovary (CHO) cells, and wherein at least 60% of the recombinant immunoglycoprotein molecules are non-fucosylated.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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