USE OF CIS-DIOL-CONTAINING POLYMER TO INHIBIT THE UPTAKE OF CATIONIC BIOCIDES INTO HYDROGEL BIOMATERIALS农业专利-农业专业知识服务系统

发明人:: KETELSON, HOWARD ALLEN,凯特森霍华德A,凱特森霍華德A,DESOUSA, RYAN,迪索沙莱恩,迪索沙萊恩,DASSANAYAKE, NISSANKE L.,达沙纳亚克尼圣克L,達沙納亞克尼聖克L,LUCK, MARY E.,路克玛莉E,路克瑪莉E

摘要：: Methods of inhibiting the uptake of cationic biocides into medical devices such as contact lenses and implants are described. Methods of stabilizing emulsions containing cationic biocides are also described. In particular, the present invention provides for the use of polymers acting as labile anionic polyelectrolytes to reversibly bind cationic biocides. The reversible binding can reduce the deleterious effects of cationic biocides while maintaining biocidal activity. Preferred polymers include galactomannan and polyvinyl alcohol.述及抑制陽離子殺生物劑被吸收進入醫學裝置諸如隱形眼鏡與植入物中之方法。亦述及含有陽離子殺生物劑的乳化液之安定化方法。尤其,本發明提供聚合物作為以可逆方式與陽離子殺生物劑結合之易變性陰離子高分子電解質之用途。該可逆性結合作用可降低陽離子殺生物劑的有害效應,同時維持其殺生物活性。較佳的聚合物包括半乳甘露聚糖與聚乙烯醇。