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PHENYLPYRROLIDINE DOPAMINE D3 RECEPTOR ANTAGONISTS
专利权人:
ABBOTT GMBH & CO. KG
发明人:
HAUPT, ANDREAS,安德亚 哈普,安德亞 哈普,GRANDEL, ROLAND,罗兰 葛戴尔,羅蘭 葛戴爾,BRAJE, WILFRIED,威菲德 伯捷,威菲德 伯捷,DRESCHER, KARLA,卡拉 德雷嘉,卡拉 德雷嘉,UNGER, LILIANE,昂哥 利利安,昂哥 利利安,TURNER, SEAN C.,西恩C 透纳,西恩C 透納,HENRY, CHRISTOPHE,克里斯多
申请号:
TW094136070
公开号:
TWI364414B
申请日:
2005.10.14
申请国别(地区):
TW
年份:
2012
代理人:
摘要:
This Hair Ming Department Off whats formula (I) compound:Wherein 0,1 or 2 n AsG As CH2 or CHR3R1 As H, C1-C6- alkyl, the C1-C6- alkyl of The C3-C6- Ring alkyl substitutions, C1-C6- Hydroxyalkyl alkyl, fluorination C1-C6- alkyl, C3-C6- Ring alkyl, fluorination C3-C6- Ring alkyl, C3-C6- alkenyls, fluorination C3-C6- alkenyls, first anilide, acetyl group or the third anilideIndependence founds As H, methyl, methyl fluoride, difluoromethyl or trifluoromethyl to R2, R3 and R4 Department each otherA As stretch phenyl, stretch pyridyl group, stretch pyrimidine radicals, stretch pyrrole  bases, stretch clatter  bases or stretch thiophenyl, can the one or more Ge Election Zi Halogen elements of The, methyl, methoxyl group and CF3 substituent group replaceE As NR5 or CH2, wherein R5 As H or C1-C3- alkylAr As Election free phenyls, including 1, 2 or 3 Ge Election are from N, 5- the or 6- STAFF Miscellaneous aromatic groups of O and S Miscellaneous atom Zuo As Ring STAFF and the Ben Ji Ring Suo Group Cheng Group Qun Ring Like bases for being fused into Eat and/or not Eat and 5- or 6- STAFF Tan Ring Huo Miscellaneous Ring Xi Ring, Qi Zhong Miscellaneous Ring Xi Ring include 1, 2 or 3 Ge Election are from N, O and S Miscellaneous atoms and/or 1, base Zuo As Ring STAFFs of each Independence Li Election of 2 or 3 Ge from NR8 Han Miscellaneous atoms, wherein R8 As H, C1-C4- alkyl, the C1-C4- alkyl of fluorination, C1-C4- alkyl-carbonyls or fluorination C1-C4- alkyl-carbonyls, and Qi Zhong Ring systems base Ar can Tapes have 1, 2 or 3 Ge substituent Rs a, wherein Change Number Ra have such as offer Yi Righteousness in Shen Please Designed benefit Fan Wai and explanationAnd its Suan Jia Cheng Which of pharmaceutical formulation. The purposes for being closed object with the position Body Medical Treatment disease disease Medical Drug Group for controlling Treatment shadows Ring by Body for controlling Treatment vulnerable to dopamine D 3 in System Prepare by Which can be connect on
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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