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Biftordioxalan-amino-benzimidazole inhibitors of kinase for the treatment of cancer, autoimmune inflammation and central nervous system disorders
专利权人:
4-ЭС-СИ ДИСКАВЕРИ ГМБХ
发明人:
Лебан, Йоханн,Зая, Мирко
申请号:
EA201500050
公开号:
EA201500050A1
申请日:
2013.06.27
申请国别(地区):
EA
年份:
2015
代理人:
摘要:
The invention relates to a compound of general formula (I) or a physiologically functional derivative, solvate or salt thereof: wherein A is a bond, alkyl or alkoxy, optionally substituted with one or more R ″ as defined herein, * —N (R ″) CO-, * -CON (R "') -, * -N (R'") CON (R '") -, -S-, -SO-, * -N (R"') -, * -N (R '") CO-, * -CON (R"') -, -CO-, * -COO-, * -OOC-, * -SON (R '") -, -SO, or * -N (R' ") -SO-, where R" is defined herein; * denotes the point of attachment to X; X represents aryl, cycloalkyl, aralkyl, heterocyclyl or heteroaryl, which may be substituted by one or more mi R, further described herein; L is a bond or * -N (R) CO-, * -CON (R) -, * -N (R) -, * -C = N (R) -, * -N (R) -alkyl, * -alkyl-N (R) -, * -N (R) CON (R) -, * -CO-, * -SO-, alkyl, * -alkyl-O-alkyl -, * -NCO-CH = CH-, * -CH = CH-CONH-, * -SON (R) -, * -N (R) SO- or heterocyclyl, where * denotes the point of attachment to X; Y is H, alkyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heteroaryl, which may be substituted by one or more R, further described herein; a R and R are additionally described herein, as well as to its use as a medicine, to a pharmaceutical composition containing it, to a method of treating or preventing a medical condition involving its administration, and to using it in the manufacture of a medicinal product for treating or preventing medical condition, in particular autoimmune inflammatory disorders, disorders of the central nervous system, sleep disorders or proliferative diseases, including cancer. The invention further relates to a specific method for producing said compounds.Изобретение относится к соединению общей формулы (I) или его физиологически функциональному производному, сольвату или соли:где А представляет собой связь, алкил или алкокси, необязательно замещенный одним или несколькими R", определенными в настоящем документе, *-N(R'")CO-, *-CON(R"')-, *-N(R'")CON(R'")-, -S-, -SO-, *-N(R"')-, *-N(R'")CO-, *-CON(R"')-, -CO-, *-COO-, *-OOC-, *-SON(R'")-, -SOи
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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