ANDRAS G. LACKO,NIRUPAMA A. SABNIS,SUNIL SHAH,LINDA K. MOOBERRY
申请号：
US16606232
公开号：
US20200138727A1
申请日:
2018.04.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides high density lipoprotein (HDL) or reconstituted HDL (rHDL) particles for the delivery of non-nucleic acid therapeutic agents, therapeutic agents or nucleic acids to cells and tissues. The use of HDL or rHDL particles has advantages over other delivery systems because they are smaller in size and their contents are rapidly internalized by receptors of specific cells, including receptors on the surface of tumor tissue. The HDL or rHDL nanoparticles of the present invention may include a positively charged polyamino acid, which neutralizes the negatively charged nucleic acid, thus allowing for successful incorporation of the nucleic acid into an HDL or rHDL particle. Methods of delivering therapeutic agents to cells and target tissues using the disclosed HDL or rHDL particles are provided as are methods of treating various diseases and disorders.
