An organ perfusion device includes an inlet for connection to the organ, and an outlet for connection to the organ. The device also includes a perfusion circuit including: a reservoir configured to hold a perfusion fluid； a waste receptacle, and a plurality of fluid conduits. The fluid conduits define: a delivery fluid path connecting the reservoir with the inlet； a return fluid path, independent of the delivery fluid path, connecting the reservoir with the outlet； and a waste fluid path connecting the reservoir with the waste receptacle. The device also includes a first flow control device configured to selectively prevent or allow fluid flow from the reservoir to the organ via the delivery fluid path； and a second flow control device configured to selectively prevent or allow fluid flow from the reservoir to the waste receptacle via the waste fluid path.
