The invention relates to methods, compositions and uses for the of treatment of cancer comprising the administration of an HDAC inhibitor as defined herein for the treatment of cancer in combination with at least one immune checkpoint modulator as defined herein.本發明涉及用於治療癌症之方法、組成物和用途,其包括與至少一種如本文所定義的免疫檢查點調節劑組合給予如本文所定義的HDAC抑制劑用於治療癌症。