PROBLEM TO BE SOLVED: To obtain a skin care preparation capable of effectively ameliorating keratinization symptom of psoriasis, ichthyosis vulgaris, palmoplantar keratosis, Darier disease, callosity, heloma or the like, dry skin, and the symptom or the like of stain, somberness and roughening of the skin, having good preparation stability, and hardly irritating the skin. SOLUTION: This skin care preparation contains (A) one or more kinds selected from the group consisting of a vegetable protease, a plant extract containing the same, and a plant extract having a protease-like activity, in combination with (B) one or more kinds selected from the group consisting of a hydroxycarboxylic acid, a salt thereof, a derivative thereof, and a plant extract containing one or more kinds of the hydroxycarboxylic acid and the like.
