A non-thermal plasma for use in the treatment of an infected nail or infected skin. The plasma is used in the method by(a) applying the plasma to the infected nail or skin(b) rehydrating the infected nail or skin(c) applying the plasma to the infected nail or skin and(d) optionally rehydrating the infected nail or skin.In each of steps (a) and (c) the plasma is applied to a portion of the nail or skin until a hydration level of the plasma-treated portion drops by at most 30 wt % based on the initial moisture content of the plasma-treated portion.