The current invention relates to medical analysis of skin Basal-cell carcinoma and melanoma by sub skin infrared imaging and 3-D tomographic reconstruction of malignant images.It is the purpose of this invention to provide methods and compositions to reliably collect data of malignant and benign lesions on the skin and beneath the surface of the skin in a non-invasive manner.Detection of a skin cancer is carried out by physical examination of the skin, or by imaging technologies of the epidermis. This is followed by biopsy of selected lesions suspected to be cancerous.The diagnostic methods of the invention are based on external imaging of lesions combined with an image taken with sub skin illumination revealing under the skin structures. A combination of the two images increases the available data, offering a better diagnostic tool.