According to one aspect, a hand assist device may be configured for use with an endoscope. The hand assist device may comprise a body configured to removably couple to a handle of the endoscope. The body may comprise a recess configured to receive the handle of the endoscope. The recess may extend from a proximal end of the body to a distal end of the body. The body may also comprise a palm support portion and a finger support portion proximal to the palm support portion. The body may further comprise a base support portion distal to the palm support portion.