KIM, HYEON JIN,HONG, SEONG TSHOOL,CHUNG, HEA JONG,JOO, MIN KYU,CHO, HEA GUK,HONG, JINNY
申请号：
EP13883393
公开号：
EP2937080A4
申请日:
2013.05.15
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
This invention encompasses targeting-enhanced anticancer nanoparticles and preparation methods for the same. In particular, this invention provides targeting-enhanced anticancer nanoparticles comprising non-covalently bound anticancer drugs, serum albumins as the nanoparticle base material, and porphyrin compounds as tumor-targeting moieties. The targeting-enhanced anticancer nanoparticles described in the present invention are characterized by non-covalently bound constituents: anticancer drugs, serum albumin as the nanoparticle base material, and porphyrin compounds as tumor-targeting moieties, thus preventing common toxic side effects, enhancing the structural stability of nanoparticles, and enhancing tumor targeting by treatment with electromagnetic waves due to the activity of porphyrin, without structural and functional changes. Taken together, the present invention provides a chemotherapeutic method that maximizes drug delivery/tumor targeting and is expected to be a successful therapy for both early-stage and late-stage cancer.
