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Vaccine against group A beta hemolytic streptococcus and respective process for obtaining thereof
专利权人:
Jorge Elias Kalil Filho;Luiza Guilherme Guglielmi
发明人:
Luiza Guilherme Guglielmi,Jorge Elias Kalil Filho
申请号:
US12516754
公开号:
US08642049B2
申请日:
2007.07.19
申请国别(地区):
US
年份:
2014
代理人:
摘要:
VACCIN AGAINST GROUP A BETA HEMOLYTIC STREPTOCOCCUS AND RESPECTIVE PROCESS FOR OBTAINING THEREOF, which predicts the production of recombinant protein cloned from the gene emm5, which contains a sequence of oligonucleotides corresponding to 52 and/or 87 amino acid residues capable of protection, isolated after the sequential molecular identification of the epitopes from the M protein carboxy-terminal region, differing in 01 amino acid residue, identified by antibodies and T lymphocytes of health human beings and of patients carriers of rheumatic fever, capable of generating a protective response by antibodies depending on the T lymphocytes; prevention of the development of the autoimmune disease by the selected epitope was evaluated in vitro with T lymphocytes from the cardiac tissue of patients with lesions arising out of rheumatic fever.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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