Compound, pharmaceutical composition, methods for treating disturbances and for degradation of target proteins, uses of a compound and a combination, and, combination.
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
CHRISTOPHER TINWORTH,JOHN DAVID HARLING
申请号：
BR112018074303
公开号：
BR112018074303A2
申请日:
2017.06.08
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
A method for treating disturbances associated with aberrant kinase activity, in which kinase I s irak3, gak, TEC, ptk2b (pyk2), aurka, rps6kakrsk3), mapk9 (jnk2), Btk, PtK2 or AKT2, the said method comprising degrading said kinase using formula compounds (i): target protein binder Call her? Binder IAP.um método para tratar distúrbios associados com atividade quinase aberrante, em que a quinase é irak3, gak, tec, ptk2b(pyk2), aurka, rps6kakrsk3), mapk9(jnk2), btk, ptk2 ou akt2, o dito método compreendendo degradar a dita quinase usando compostos de fórmula (i): aglutinante de proteína-alvo ? ligante ?aglutinante iap.
