María Luz Ortiz Melguizo, legal representative;Ángel Messeguer Peypoch;Johanna Scheper Sigmund;Timothy Thomson Okatsu;Ma Carmen Fabrega Claveria, legal representative;Ángel Ramírez Ortiz;Gloria Sancli
发明人:
Timothy Thomson Okatsu,Johanna Scheper Sigmund,Ángel Messeguer Peypoch,Ángel Ramírez Ortiz,Gloria Sanclimens Pérez de Rozas,Isabel Masip Masip,Alejandra Moure Fernández,Domingo González Ruiz,Antonio M
申请号：
US12309429
公开号：
US08252786B2
申请日:
2007.03.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to a compound (I) wherein R is a heterocyclyl radical； R1 and R2 are independently H or alkyl； R3 is H, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl； R4 and R5 are independently H or alkyl； q is a number selected from 0 and 1； and the salts, solvates, prodrugs or stereoisomers thereof having inhibitory activity for UBC13-UEV interactions and which can be used in the production of pharmaceutical compositions intended for antitumor therapy or the treatment and/or prophylaxis of diseases associated to metabolic pathways involving the UBC13 enzyme, metabolic pathways involving transcriptional factor NF-κB, or pathways involving PCNA or RAD6.R—(CR1R2)q-CO—N(R3)—C(R4R5)—CO—NH2 (I)
