THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
发明人:
Suresh Kumar Thallapuranam,David A. Zaharoff,Srinivas Jayanthi,Bhanuprasanth Koppolu,Rebecca Kerr,Kartik Balachandran,David S. McNabb
申请号：
US15474268
公开号：
US10385113B2
申请日:
2017.03.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.
