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MATERIAL PRODUCTION AND APPLICATION USING AZOLE FUNCTIONALIZED NANOSILICA
- 专利权人:
- Imam Abdulrahman Bin Faisal University
- 发明人:
- Sarah Mousa ASIRI,Firdos Alam KHAN,Ayhan BOZKURT
- 申请号:
- US16380356
- 公开号:
- US20200323996A1
- 申请日:
- 2019.04.10
- 申请国别(地区):
- US
- 年份:
- 2020
- 代理人:
- 摘要:
- A combination therapy involving different therapeutic molecules can enhance and improve the therapeutic potentials. An effective therapeutic strategy conjugates silica (SiO2) nanoparticles with, e.g., 3-glycidyloxypropyl, trimethoxysilane and azoles, e.g., 1,2,4-triazole (Tri), 3-aminotriazole (ATri), 5-aminetetrazole (Atet), imidazole (Imi). These exemplary materials—;classified as SiO2-3GPS-Tri (Conj. 1), SiO2-3GPS-Atri (Conj. 2), SiO2-3GPS-Atet (Conj. 3), SiO2-3GPS-Btri (Conj. 4), and SiO2-3GPS-Imi (Conj. 5)—;can amplify targeting of therepeutics for human colorectal carcinoma cells (HCT-116), enhancing anti-cancer effects.
- 来源网站:
- 中国工程科技知识中心
- 来源网址:
- http://www.ckcest.cn/home/