molecular crystalline form, use of molecular form, and method for preparing a molecular material.

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专利权人:

BAUSCH & LOMB INCORPORATED

发明人:

HARRY M. KING JR.

申请号：

BRPI1009849

公开号：

BRPI1009849A2

申请日:

2010.03.18

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

Disclosed herein is a molecular crystal form of the compound (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-1H-azepin-1-yl)-1-cyclopropyl-8-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid. The molecular crystal is characterized by at least one of: (a) an X-ray powder diffraction ("XRPD") spectrum that comprises peaks at 2theta angles of 10.6, 15, 19.7, 21.1, and 22°±0.2°； (b) a DSC melting peak at 288° C.； (c) a 13C NMR spectrum having peaks at 23.3, 27.7, 41.1, 54.5, 116.6, and 153.5 ppm； and (d) pKa values of 5.65 and 9.91. The compound belongs to the class of fluoroquinolones and is useful as an antibacterial agent.

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