BENATUIL Lorenzo,ARGIRIADI Maria A.,MCRAE Bradford L.,HSIEH Chung-Ming,EGAN David A.,HARLAN John E.,JUDGE Russell A.,WANG Rui,KINGSBURY Gillian A.
申请号：
SI201630637
公开号：
SI3303395T1
申请日:
2016.05.27
申请国别(地区):
SI
年份:
2020
代理人:
摘要：
The present invention encompasses antagonist anti-CD40 antibodies and antigen-binding portions thereof. Specifically, the invention relates to humanized anti-CD40 antibodies. In certain embodiments, antibodies of the invention neutralize human CD40 (hCD40) activity. Antibodies, or antibody portions, of the invention are useful for detecting CD40 and for inhibiting CD40 activity, e.g., in a human subject suffering from a disorder in which CD40 activity is detrimental.
