SACURAL, Srgio Luiz,ZAIM, Mrcio Henrique,TOUZARIM, Carlos Eduardo da Costa,KEPPLER, Artur Franz,DE NUCCI, Gilberto,塞爾希奧.路易斯.薩克瑞,馬爾西奧.恩裏克.紮伊姆,卡洛斯.愛德華多.達.科斯塔,阿圖爾.弗朗茨.開普勒,吉爾伯托.德.努奇
申请号：
HK13112233.7
公开号：
HK1184786B
申请日:
2013.10.30
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
A series of derivatives of 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione, mixtures thereof, their pharmaceutically acceptable salts, which are inhibitors of PDE-5, possessing vasodilatator properties and relaxing effects. In particular, compounds of formula (I), where R1, R2, R3, and R4 are defined herein, processes for the preparation of said compounds, pharmaceutical compositions containing them, as well as uses as inhibitors of the enzyme phosphodiesterase type 5 (PDE-5) in the treatment of the erectile dysfunction and PDE-5 inhibitor treatable disorders.
