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"nucleic acid complex and nucleic acid-delivering composition"
专利权人:
发明人:
HIROFUMI TAKEUCHI,YUICHI TOZUKA,MITSUTAKA MURATA,HIDEKAZU TOYOBUKU
申请号:
IN6397/DELNP/2011
公开号:
IN2011DN06397A
申请日:
2011.08.23
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
This invention relates to a nucleic acid complex with low toxicity and high safety that can maintain a nucleic acid molecule capable of RNA interference or translation inhibition, such as siRNA or the like, in a cell and a nucleic acid delivery composition that can efficiently deliver the nucleic acid complex into a cell. A nucleic acid complex with low toxicity and high safety that can maintain a nucleic acid in a cell can be obtained by forming a complex using a nucleic acid molecule capable of RNA interference or translation inhibition and a cycloamirose. Further, by using a carrier comprising (A) a diacylphosphatidylcholine, (B) cholesterol and/or a derivative thereof, and (C) an aliphatic primary amine as a nucleic acid delivery carrier to introduce the nucleic acid complex into a cell, the safety, efficiency of intracellular delivery, and persistence of the nucleic acid in the cell can be further improved.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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