Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HBV and/or HDV and/or HIV infection with one or more nucleotide analogs.本文所揭示者係核苷酸類似物、合成核苷酸類似物的方法、及用一或多種核苷酸類似物來治療疾病及/或病況(諸如HBV及/或HDV及/或HIV感染)的方法。