Methods for treatment of infections, such as nasal infections, sinus infections, ear infections, and/or lung infections, along with related compositions. In some implementations, a treatment method may comprise delivering a dose of the composition into a subject's nasal passage to treat the infection. The composition may comprise an antibiotic agent, such as ciprofloxacin. The composition may further comprise at least one non-hexose, sugar alcohol, such as xylitol. Preferably, the dose comprises a sub-clinical dose of the ciprofloxacin or other antibiotic agent.
