The present invention relates to materials having cell proliferation properties, said materials comprising a polymer having incorporated therein a synergistic combination of at least two metal oxide powders, comprising a mixed oxidation state oxide of a first metal and a single oxidation state oxide of a second metal, wherein the mixed oxidation state oxide constitutes from about 25% wt. to about 75% wt. of the total weight of the synergistic combination of the at least two metal oxide powders, the powders are being incorporated substantially uniformly within said polymer, and the ions of the metal powders are in ionic contact upon exposure of said material to moisture. There are further provided methods for the preparation of said materials and uses thereof, including in skin regeneration processes and cosmetic applications.本發明係關於具有細胞增殖特性的材料，該等材料包含其中併入至少兩種金屬氧化物粉末之協同組合的聚合物，該協同組合包含第一金屬之混合氧化態氧化物及第二金屬之單一氧化態氧化物，其中該混合氧化態氧化物佔至少兩種金屬氧化物粉末之協同組合之總重量的約25wt.%至約75wt.%，該等粉末係實質上均勻地併入該聚合物內，且在該材料暴露於水分後，該等金屬粉末的離子處於離子性接觸。另外提供製備該等材料的方法及其用途，包括皮膚再生方法及化妝品應用。
