The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.本發明係關於用於製備、純化、調配及使用生物學活性重組彈性蛋白酶蛋白質之方法。本發明描述用於產生治療上適用之彈性蛋白酶蛋白質之重組方法，亦描述包含該等彈性蛋白酶蛋白質之醫藥組合物。亦揭示新穎重組彈性蛋白酶蛋白質及蛋白質製劑。描述使用含有本發明之彈性蛋白酶蛋白質的醫藥組合物治療及預防生物管道疾病之方法。
