Dae Jin KIM,Jong Soo LEE,Young Jin PARK,Sung Hee HONG,Sung Min BAE,Se Chang KWON
申请号：
US15762661
公开号：
US20180326013A1
申请日:
2016.09.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex prepared by the present invention may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.
