The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.本發明一般係關於調節TGFβR-1及TGFβR-2活性之化合物、含有該等化合物之醫藥組合物及採用本發明化合物治療增殖性病症及細胞凋亡失調性病症(諸如癌症)之方法。