Through the linkage editor numerator which is made to join without deteriorating the water solubility macromolecule vis-a-vis the titanium oxide complex grain which is made to distribute in the water system solvent due to the water solubility macromolecule, low by the fact that qualification the numerator which includes the valence succession metal, furthermore the ultrasonic cancer treatment accelerator which is the titanium oxide - metal complex grain which grants the continuous anti- tumor effect is offered without losing detachability and catalytic converter activity. While with this invention, on the titanium oxide surface of the titanium oxide complex grain which is made to distribute in the water system solvent due to the water solubility macromolecule, the carboxyl group, the amino group, the diol basis, through one which is chosen from the group of salicyl acid radical, and phosphorus acid radical functional group at least, making the linkage editor numerator join, furthermore through the linkage editor numerator, low by the fact that qualification the numerator which includes the valence succession metal, maintaining detachability and catalytic converter activity, furthermore it granted the continuous anti- tumor effect, it can offer the ultrasonic cancer treatment accelerator which is the titanium oxide - metal complex grain. It can integrate this ultrasonic cancer treatment accelerator to the affected part, it can utilize as the medicine for remedying which is adjusted to ultrasonic lighting.水溶性高分子により水系溶媒中で分散させた酸化チタン複合体粒子に対して、水溶性高分子を変質させることなく結合させたリンカー分子を介して低原子価遷移金属を含む分子を修飾することで、分散性と触媒活性を失うことなく、さらに持続的な抗腫瘍効果を付与した酸化チタン-金属複合体粒子である超音波癌治療促進剤が提供される。本発明では、水溶性高分子により水系溶媒中で分散させた酸化チタン複合体粒子の酸化チタン表面に、カルボキシル基、アミノ基、ジオール基、サリチル酸基、およびリン酸基の群から選択される少なくともひとつの官能基を介してリンカー分子を結合させ、さらにリンカー分子を介して低原子価遷移金属を含む分子を修飾することで、分散性と触媒活性を保ちながら、さらに持続的な抗腫瘍効果を付与した、酸化チタン-金属複合体粒子である超音波癌治療促進剤を提供できる。この超音波癌治療促進剤は患部に集積し、超音波照射と併せた治療のための薬剤として利用できる。
